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piperazine theophylline ethanoateThe published official price. Pharmacies may differ slightly.
The medical information below is guidance and may be incomplete or wrong. Do not change your medicine or dose based on it — ask a pharmacist or doctor.
Piperazine theophylline ethanoate (etofylline or etamiphylline) is a xanthine derivative bronchodilator used for the symptomatic relief of bronchospasm in asthma, chronic obstructive pulmonary disease (COPD), and other reversible airways obstruction.
Contraindicated in patients with known hypersensitivity to xanthine derivatives, piperazine, or ethanoate compounds. Use with caution in patients with cardiac arrhythmias, peptic ulcer, seizure disorders, or hepatic impairment.
Side effects include nausea, vomiting, headache, tachycardia, palpitations, insomnia, and irritability. At toxic levels, theophylline derivatives may cause arrhythmias and seizures. The piperazine component carries a low risk of neurotoxicity.
Monitor for signs of toxicity including nausea, arrhythmias, and agitation, especially in patients with hepatic or cardiac disease. Avoid concurrent use with other xanthine derivatives or medications that inhibit xanthine metabolism.
Etamiphylline (piperazine theophylline ethanoate) acts primarily as a phosphodiesterase inhibitor, increasing intracellular cyclic AMP. This leads to smooth muscle relaxation in the bronchi, causing bronchodilation. It also has mild stimulant effects on the respiratory center and mild diuretic properties.
Store at room temperature away from heat, moisture, and direct light. Keep out of reach of children.